Related Experiment Video

Updated: Oct 25, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

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Coronavirus Disease 2019 in a Patient With a Systemic Autoinflammatory Syndrome due to an NLRC4 Inflammasomopathy

Jeffrey K Duncan-Lowey1,2, Vaidehi Chowdhary3, Dana W Dunne1

  • 1Section of Infectious Diseases, Department of Medicine. Yale University School of Medicine, New Haven, Connecticut, USA.

Open Forum Infectious Diseases
|August 11, 2021
PubMed

Insights

Autoinflammatory diseases

Area of Science:

  • Immunology
  • Infectious Diseases
  • Genetics

Background:

  • The impact of autoinflammatory diseases on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood.
  • Autoinflammatory diseases involve dysregulation of the innate immune system, potentially affecting viral responses.

Purpose of the Study:

  • To describe a case of coronavirus disease 2019 (COVID-19) in a patient with a specific autoinflammatory disease.
  • To explore the implications of immunosuppression in managing COVID-19 in patients with autoinflammation.

Main Methods:

  • Case report detailing a patient with autoinflammation with infantile enterocolitis.
  • Genetic analysis identifying a mutation in the NLRC4 inflammasome component.
  • Clinical observation of the patient's COVID-19 course.

Main Results:

  • The patient presented with COVID-19.
  • The patient had a history of autoinflammation with infantile enterocolitis due to an NLRC4 mutation.
  • The case underscores the importance of considering immunosuppression in autoinflammatory patients with COVID-19.

Conclusions:

  • This case highlights the complex interplay between autoinflammatory diseases, genetic mutations (NLRC4), and viral infections like COVID-19.
  • Immunosuppressive therapies in autoinflammation may influence the clinical course and management of SARS-CoV-2 infection.
Keywords:
COVID-19NLRC4SARS-CoV-2autoinflammatoryinflammasome

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