A meta-analysis on continuous versus interrupted skin closure following appendicectomy

Area of Science:

• Surgical techniques
• Wound healing
• Evidence-based medicine

Background:

• Open appendectomies are common surgical procedures.
• Wound closure methods impact patient outcomes.
• Comparing continuous subcuticular and interrupted transdermal closures is crucial.

Purpose of the Study:

• To analyze randomized controlled trials (RCTs) comparing wound-related outcomes.
• To evaluate continuous subcuticular versus interrupted transdermal wound closures.
• To assess outcomes in all age groups undergoing open appendectomies.

Main Methods:

• Systematic literature search conducted in April 2020 across multiple databases.
• Inclusion of RCTs regardless of language, publication status, or patient age.
• Pooled risk ratios and mean differences calculated using random-effects models.

Main Results:

• Eleven trials (1781 patients) were analyzed.
• No significant difference in wound infection or exploration rates.
• Continuous closure significantly reduced wound dehiscence (RR 0.16) and improved scar appearance (MD -2.11 mm).

Conclusions:

• Continuous subcuticular closure is safe regarding infection and exploration.
• This method offers reduced wound dehiscence and superior cosmetic results.
• Further research may be needed considering the high risk of bias in included RCTs.