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Related Experiment Video

Updated: Oct 25, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Microphysiological systems in absorption, distribution, metabolism, and elimination sciences.

Kirk P Van Ness¹, Francine Cesar¹, Catherine K Yeung^2,3

¹Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.

Clinical and Translational Science

|August 11, 2021

Summary

This summary is machine-generated.

Microphysiological systems (MPS) advance drug safety testing by enabling absorption, distribution, metabolism, and elimination (ADME) assessments. This review evaluates liver, kidney, and intestinal MPS for regulatory-compliant drug ADME evaluations.

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Published on: February 23, 2018

Area of Science:

Pharmacology
Toxicology
Biotechnology

Background:

Microphysiological systems (MPS) adoption is increasing for drug absorption, distribution, metabolism, and elimination (ADME) studies.
Regulatory and industry demand is shifting away from animal testing towards in vitro methods.
Technological advancements in cell culture, fluidics, and materials have enabled sophisticated MPS.

Purpose of the Study:

To review current MPS for liver, kidney, and intestinal ADME evaluation.
To assess these systems against regulatory and expert-recommended performance criteria.
To identify suitable MPS for drug ADME research.

Main Methods:

Survey of existing liver, kidney, and intestinal MPS.
Evaluation of MPS based on performance criteria for ADME studies.
Analysis of system suitability for regulatory acceptance.

Main Results:

Various MPS designs exist for standalone or interconnected organ systems.
Some systems are better suited for ADME research than others.
Not all current MPS designs meet recently published performance criteria.

Conclusions:

MPS technology is rapidly advancing for drug ADME assessment.
Further development and validation are needed for some MPS to meet performance standards.
MPS show significant promise for improving drug safety and development efficiency.