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Updated: Oct 25, 2025

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Re-emphasising the importance of histopathological diagnosis in suspected bacterial endocarditis
Hafiz Naderi1, Aula Abbara1, Alessandro Viviano1
1Department of Cardiology, Imperial College Healthcare NHS Foundation Trust, London, UK.
Abstract:
Infective endocarditis (IE) carries a high risk of morbidity and mortality. Timely diagnosis, effective treatment and prompt recognition of complications are essential to favourable patient outcomes. A collaborative, multidisciplinary team approach to the management of IE has been shown to improve prognosis. However, the clinical heterogeneity of IE and atypical presentations pose challenges to the endocarditis team. We present a case highlighting the role of valve histopathology in suspected IE, where there may be diagnostic uncertainty.
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