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Updated: Oct 25, 2025

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

A reference scale of cucurbit[7]uril binding affinities.

Mohammad A Alnajjar¹, Werner M Nau¹, Andreas Hennig^1,2

¹Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany. w.nau@jacobs-university.de.

Organic & Biomolecular Chemistry

|August 11, 2021

Summary

This summary is machine-generated.

This study introduces a new reference scale for determining ultra-high binding affinities in supramolecular chemistry using cucurbit[7]uril (CB7) hosts. This scale aids in precisely measuring binding strengths for advanced host-guest systems.

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Published on: March 17, 2010

Area of Science:

Supramolecular Chemistry
Chemical Thermodynamics
Host-Guest Chemistry

Background:

Accurate determination of ultra-high binding affinities (>10^6 M^-1) in host-guest chemistry is challenging.
Direct titration methods are limited by sensitivity, necessitating competitive titration approaches.
Competitive titrations require reliable reference compounds with well-established binding affinities.

Purpose of the Study:

To establish a reference scale for competitive titrations involving cucurbit[7]uril (CB7).
To facilitate the accurate determination of binding affinities for CB7 in the range of 10^3 to 10^15 M^-1.
To support the study of stimuli-responsive host-guest systems.

Main Methods:

Development of a reference scale using commercially available compounds.
Application of competitive titration techniques with cucurbit[7]uril (CB7) as the host.
Validation of the reference scale across a broad affinity range.

Main Results:

A comprehensive reference scale for CB7 binding affinities from 10^3 to 10^15 M^-1 has been established.
The proposed reference compounds are readily accessible, simplifying experimental procedures.
The scale provides a reliable framework for future affinity measurements.

Conclusions:

The developed reference scale significantly advances the ability to quantify high binding affinities in CB7-based supramolecular systems.
This resource will accelerate research in stimuli-responsive host-guest chemistry.
The availability of standardized references enhances reproducibility and comparability in the field.