GASTRIC RESIDUAL VOLUME FACTORS AFTER BOWEL PREPARATION WITH MANNITOL EXPRESS

Area of Science:

• Gastroenterology
• Clinical Medicine
• Pharmacology

Background:

• Mannitol is a common bowel preparation agent in Brazil.
• Factors influencing gastric emptying time after mannitol preparation require investigation.
• Understanding these factors can optimize patient preparation and scheduling.

Purpose of the Study:

• To identify factors affecting gastric emptying time following mannitol bowel preparation.
• To analyze the relationship between patient characteristics, medications, and gastric residual volume.

Main Methods:

• Prospective observational study involving 103 patients undergoing colonoscopy.
• Gastric content was aspirated via upper endoscopy before colonoscopy.
• Data collected included diet, comorbidities, medications, surgical history, and bowel movement patterns.

Main Results:

• Average gastric residual volume (GRV) was 120.9 mL.
• GRV ≤100 mL was associated with longer fasting times (123.1 min) compared to GRV >100 mL (95.3 min).
• Ezetimibe use correlated with lower GRV, while paroxetine, tadalafil, and history of prostatectomy/bridle withdrawal correlated with higher GRV.

Conclusions:

• Fasting for over 2 hours post-mannitol and ezetimibe use significantly decrease the likelihood of elevated GRV (>100 mL).
• Paroxetine, tadalafil, and surgical history (prostatectomy, bridle withdrawal) may increase the incidence of high GRV.
• These findings aid in personalized patient guidance for mannitol bowel preparation.