[Treatment of Sydenham's chorea with perphenazine]

Symptomatic therapy in Sydenham's chorea has not been satisfactory. Perphenazine was tested as an alternative to diminish abnormal movements. A Syndenham's chorea comparative double-blind study (17 patients) using it, with reserpine and placebo as controls, was designed. Perphenazine was tried also in another open-study (13 patients with Syndenham's chorea). Out of the 2 groups, those which received perphenazine improved earlier and in a greater proportion than controls, with statistical significance (p is less than 0.01).