Related Experiment Video
Updated: Oct 25, 2025
10:33
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
2.9K
Acute Uveitis following COVID-19 Vaccination
Reem H ElSheikh1, Abid Haseeb2, Taher K Eleiwa3
1Department of Ophthalmology, Cairo University Hospitals, Cairo, Egypt.
Ocular Immunology and Inflammation
|August 11, 2021
Summary
A case report details juvenile idiopathic arthritis-associated anterior uveitis following the Sinopharm COVID-19 vaccine. This finding suggests a potential link between the vaccine and the onset of ocular inflammation in susceptible individuals.
Area of Science:
- Ophthalmology
- Rheumatology
- Vaccinology
Background:
- Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition that can affect various joints.
- Anterior uveitis is a common ocular complication associated with JIA, potentially leading to vision impairment.
- The Sinopharm COVID-19 vaccine is an inactivated virus vaccine used globally.
Observation:
- An 18-year-old female with a history of antinuclear antibody-positive oligoarticular JIA developed bilateral anterior uveitis.
- Symptoms appeared five days after receiving the second dose of the Sinopharm COVID-19 vaccine.
- Anterior segment optical coherence tomography revealed characteristic findings of circulating inflammatory cells in the anterior chamber.
Findings:
- The patient presented with bilateral anterior uveitis, characterized by reduced visual acuity.
- Anterior segment OCT confirmed inflammatory cells within the anterior chamber.
- Ocular inflammation resolved with topical corticosteroid therapy, showing no recurrence.
Implications:
- This case suggests a potential association between the Sinopharm COVID-19 vaccine and the development of anterior uveitis in patients with JIA.
- Further research is warranted to investigate the immunogenic mechanisms and establish causality.
- Monitoring for ocular side effects in JIA patients post-vaccination may be beneficial.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
899
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
899
01:27Open Angle Glaucoma: Treatment
770
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
770
01:25Glaucoma: Overview
1000
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1000
01:30Acute Pharyngitis
2.2K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
2.2K
01:27Acute Pyelonephritis I: Introduction
141
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
141
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
83
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
83