Related Experiment Video

Updated: Oct 25, 2025

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

7.8K

Smooth-talking T cells leave asthma breathless

Artem Romanov1, Sonia Sharma1

  • 1La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Immunity
|August 11, 2021
PubMed

Insights

The plasma membrane channel PANX1 releases nucleotides. This study reveals PANX1

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • The plasma membrane channel PANX1 (pannexin 1) facilitates the release of bioactive molecules.
  • Its specific role within immune cells, particularly T cells, remains largely uncharacterized.

Purpose of the Study:

  • To investigate the function of PANX1 in immune cells.
  • To elucidate the role of PANX1 in the context of allergic airway inflammation.

Main Methods:

  • Utilized techniques to study PANX1's role in CD4+ T cell subsets.
  • Investigated mechanisms of adenosine-dependent cell communication.

Main Results:

  • PANX1 mediates the release of adenine nucleotides, including adenosine.
  • Demonstrated that PANX1 is crucial for adenosine-dependent communication between regulatory and effector CD4+ T cells.
  • Showcased PANX1's involvement in allergic airway inflammation.

Conclusions:

  • PANX1 plays a significant role in immune cell communication.
  • Targeting PANX1 may offer a therapeutic strategy for allergic airway diseases.

More Related Videos

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

15.2K
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

7.1K

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.4K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
860
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
718
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.9K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
723
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.6K