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Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development.

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Microphysiological systems (MPS) offer advanced in vitro human physiology models. Overcoming adoption barriers requires bridging gaps between developers, users, and regulatory bodies for wider use.

Keywords:
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Area of Science:

  • Biotechnology
  • Physiology
  • In vitro modeling

Background:

  • Microphysiological systems (MPS), also known as tissue chips or organs-on-chips, are innovative in vitro models.
  • These systems aim to replicate human physiology at a fundamental functional level.

Purpose of the Study:

  • To review the hurdles hindering the widespread adoption of MPS technology.
  • To identify challenges from academic developers, commercial suppliers, pharmaceutical/biotechnology industries, and regulatory organizations.
  • To offer perspectives on overcoming these obstacles for broader MPS implementation.

Main Methods:

  • Literature review and analysis of stakeholder perspectives.
  • Identification of translation gaps between MPS developers and end-users.
  • Examination of barriers faced by various sectors including industry and regulatory bodies.

Main Results:

  • Widespread adoption of MPS is limited by a significant translation gap.
  • Barriers exist across academic, commercial, industrial, and regulatory sectors.
  • End-users can play a crucial role in overcoming these adoption challenges.

Conclusions:

  • Addressing the identified barriers is essential for the successful integration of MPS technology.
  • Collaboration and improved communication among stakeholders are key to advancing MPS adoption.
  • End-user engagement can facilitate the surmounting of obstacles to achieve broader utilization of MPS.