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Detection of intracranial hypertension in children using optical coherence tomography: a systematic review

Sohaib R Rufai1,2,3, Michael Hisaund1, Noor Ul Owase Jeelani2

  • 1University of Leicester Ulverscroft Eye Unit, Leicester Royal Infirmary, Leicester, UK.

BMJ Open
|August 12, 2021
PubMed

Insights

Optical coherence tomography (OCT) shows promise in diagnosing intracranial hypertension (IH) in children. Further high-quality studies are needed to establish optimal parameters and clinical guidelines for its use.

Area of Science:

  • Ophthalmology
  • Pediatric Neurology
  • Medical Imaging

Background:

  • Intracranial hypertension (IH) in children requires accurate diagnostic methods.
  • Optical coherence tomography (OCT) is a non-invasive imaging technique with potential diagnostic applications.

Purpose of the Study:

  • To evaluate the diagnostic capability of OCT for intracranial hypertension (IH) in pediatric patients.
  • To systematically review existing literature on OCT for IH diagnosis in children under 18.

Main Methods:

  • A systematic review was conducted using multiple databases (PubMed, EMBASE, etc.) with keywords 'optical coherence tomography' and 'intracranial hypertension'.
  • Studies were screened, and data from included studies were graded for quality and level of evidence.

Main Results:

  • Twenty-one studies were included, encompassing conditions like craniosynostosis, idiopathic IH, and space-occupying lesions.
  • OCT demonstrated good diagnostic capability for IH in various pediatric conditions, though parameter and reference measure inconsistencies were noted.

Conclusions:

  • OCT shows potential in assisting the diagnosis and management of IH in children, alongside established clinical measures.
  • High-quality prospective studies are necessary to validate OCT parameters and develop formal clinical guidelines.
Abstract

Keywords:
neuro-ophthalmologyneurological oncologypaediatric neurologypaediatric neurosurgerypaediatric ophthalmologyplastic & reconstructive surgery

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