Role of Inferior Frontal Junction (IFJ) in the Control of Feature versus Spatial Attention

Feature-based visual attention refers to preferential selection and processing of visual stimuli based on their nonspatial attributes, such as color or shape. Recent studies have highlighted the inferior frontal junction (IFJ) as a control region for feature but not spatial attention. However, the extent to which IFJ contributes to spatial versus feature attention control remains a topic of debate. We investigated in humans of both sexes the role of IFJ in the control of feature versus spatial attention in a cued visual spatial (attend-left or attend-right) and feature (attend-red or attend-green) attention task using fMRI. Analyzing cue-related fMRI using both univariate activation and multivoxel pattern analysis, we found the following results in IFJ. First, in line with some prior studies, the univariate activations were not different between feature and spatial attentional control. Second, in contrast, the multivoxel pattern analysis decoding accuracy was above chance level for feature attention (attend-red vs attend-green) but not for spatial attention (attend-left vs attend-right). Third, while the decoding accuracy for feature attention was above chance level during attentional control in the cue-to-target interval, it was not during target processing. Fourth, the right IFJ and visual cortex (V4) were observed to be functionally connected during feature but not during spatial attention control, and this functional connectivity was positively associated with subsequent attentional selection of targets in V4, as well as with behavioral performance. These results support a model in which IFJ plays a crucial role in top-down control of visual feature but not visual spatial attention.SIGNIFICANCE STATEMENT Past work has shown that the inferior frontal junction (IFJ), a prefrontal structure, is activated by both attention-to-feature (e.g., color) and attention-to-location, but the precise role of IFJ in the control of feature- versus spatial-attention is debated. We investigated this issue in a cued visual spatial (attend-left or attend-right) and feature (attend-red or attend-green) attention task using fMRI, multivoxel pattern analysis, and functional connectivity methods. The results show that (1) attend-red versus attend-green can be decoded in single-trial cue-evoked BOLD activity in IFJ but not attend-left versus attend-right and (2) only right IFJ modulates V4 to enhance task performance. This study sheds light on the function and hemispheric specialization of IFJ in the control of visual attention.