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Mismatch repair mutations: Biomarker for immunotherapy in colorectal cancers

Santosh Shenoy1

  • 1Department of Surgery, Kansas City VA Medical Center, University of Missouri Kansas City, USA.

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|August 12, 2021
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No abstract available in PubMed .

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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