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Related Experiment Video

Updated: Oct 25, 2025

Preterm EEG: A Multimodal Neurophysiological Protocol
19:32

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Published on: February 18, 2012

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Multi-Omics Analysis on Neurodevelopment in Preterm Neonates: A Protocol Paper.

Sharon G Casavant, Jie Chen, Wanli Xu

    Nursing Research
    |August 12, 2021
    PubMed
    Summary
    This summary is machine-generated.

    The gut microbiome influences preterm infant health. This study protocol aims to link infant gut bacteria, pain, genetics, and neurodevelopmental outcomes in neonatal intensive care units.

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    Area of Science:

    • Neonatal research
    • Microbiome studies
    • Developmental pediatrics

    Background:

    • The gut microbiome plays a critical role in the health and disease of preterm infants.
    • Understanding these microbial communities is essential for improving infant outcomes.

    Purpose of the Study:

    • To present a protocol for characterizing the relationship between the intestinal microbiome and health outcomes in preterm infants.
    • To enable other neonatal intensive care units to expand their existing protocols.

    Main Methods:

    • Prospective, longitudinal study of preterm infants (<32 weeks gestational age or <1,500 g).
    • Data collection includes early life pain/stress, gut microbiome, host genetics, and neurobehavioral assessments during the neonatal intensive care unit stay.
    • Follow-up assessments of gut microbiome, pain sensitivity, medical, growth, and developmental outcomes at corrected ages of 4, 8-12, and 18-24 months.

    Main Results:

    • As of February 14, 2020, 214 preterm infants have been recruited.
    • Hypothesis: Increased pain/stress in infants correlates with altered gut microbiome and adverse outcomes (necrotizing enterocolitis, feeding intolerance, neurodevelopmental impairments).
    • Investigating the impact of microbiome alterations on the risk of these adverse outcomes and the interaction with host genetics.

    Conclusions:

    • The study protocol aims to elucidate the complex interplay between the gut microbiome, pain, genetics, and health outcomes in preterm infants.
    • Findings will inform clinical practices in neonatal intensive care units to potentially improve long-term health and development.