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Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Related Experiment Video

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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

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Possible Bioenergetic Biomarker for Chronic Cancer-Related Fatigue.

Chao-Pin Hsiao, Barbara Daly, Mei-Kuang Chen

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    |August 12, 2021
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    Summary
    This summary is machine-generated.

    Cancer-related fatigue (CRF) is common in prostate cancer patients undergoing radiation. This study identified downregulated BCS1L gene expression as a potential biomarker for chronic CRF, offering new therapeutic targets.

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    The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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    Area of Science:

    • Oncology
    • Genetics
    • Biomarkers

    Background:

    • Cancer-related fatigue (CRF) significantly impacts patients undergoing cancer treatment, with up to 71% of men with prostate cancer experiencing it during radiation therapy.
    • Currently, effective therapies and diagnostic biomarkers for CRF are lacking.
    • This pilot study focused on identifying potential biomarkers for chronic CRF in men with prostate cancer receiving radiation therapy.

    Purpose of the Study:

    • To discover potential biomarkers associated with chronic cancer-related fatigue (CRF).
    • To investigate the relationship between gene expression in peripheral blood mononuclear cells and CRF.
    • To explore BCS1L as a potential biomarker for CRF in prostate cancer patients undergoing radiation therapy.

    Main Methods:

    • A longitudinal study design was employed with 20 men with prostate cancer undergoing radiation therapy.
    • CRF was assessed using the Patient-Reported Outcomes Measurement Information System for Fatigue (PROMIS-F) Short Form.
    • Messenger RNA (mRNA) gene expression of mitochondria-related genes, specifically BCS1L, was quantified in peripheral blood mononuclear cells at multiple time points.

    Main Results:

    • Patient-reported fatigue scores (PROMIS-F) significantly increased over time and remained elevated 24 months post-radiation therapy.
    • A significant downregulation of BCS1L mRNA was observed during and up to 24 months after radiation therapy.
    • An inverse trend was noted between increased fatigue scores and downregulated BCS1L expression 24 months post-radiation therapy.

    Conclusions:

    • This study provides the first evidence of altered BCS1L mRNA in chronic CRF among men with prostate cancer receiving radiation therapy, measured by PROMIS-F.
    • Peripheral blood mononuclear cell mRNA for BCS1L shows promise as a biomarker for radiation therapy-induced chronic CRF.
    • BCS1L may represent a potential therapeutic target for managing chronic CRF in this patient population.