Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis

Area of Science:

• Oncology
• Molecular Biology
• Cell Death Research

Background:

• Distant metastasis is a primary cause of cancer-related mortality.
• Programmed cell death pathways, including necroptosis, pyroptosis, and ferroptosis, are increasingly recognized for their role in tumor progression and metastasis.
• Non-coding RNAs are critical regulators of cellular processes, including programmed cell death and cancer metastasis.

Purpose of the Study:

• To review the functions and roles of necroptosis, pyroptosis, and ferroptosis in cancer metastasis.
• To summarize the regulatory mechanisms of these programmed cell death pathways by non-coding RNAs during tumor metastasis.

Main Methods:

• Literature review of recent studies on programmed cell death and non-coding RNA in cancer metastasis.
• Synthesis of findings on the involvement of necroptosis, pyroptosis, and ferroptosis in tumor spread.
• Analysis of non-coding RNA-mediated regulation of these cell death pathways in the context of metastasis.

Main Results:

• Necroptosis, pyroptosis, and ferroptosis play significant roles in modulating the tumor microenvironment and facilitating cancer cell dissemination.
• Non-coding RNAs, such as microRNAs and long non-coding RNAs, are key players in controlling the initiation and execution of these cell death pathways.
• Dysregulation of non-coding RNA expression can promote or inhibit cancer metastasis by altering programmed cell death signaling.

Conclusions:

• Programmed cell death pathways (necroptosis, pyroptosis, ferroptosis) are critical targets for understanding and combating cancer metastasis.
• Non-coding RNAs represent a vital layer of regulation in these processes, offering potential therapeutic avenues.
• Further research into the interplay between non-coding RNAs and programmed cell death is essential for developing effective anti-metastatic strategies.