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Altered platelet and coagulation function in moderate-to-severe COVID-19
Rustem I Litvinov1,2, Natalia G Evtugina2, Alina D Peshkova2
1Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Scientific Reports
|August 12, 2021
Summary
COVID-19 causes hypercoagulability, linked to inflammation and severity. Impaired blood clot contraction in patients suggests microthrombosis, necessitating hemostasis monitoring and thrombotic complication prophylaxis.
Area of Science:
- Hematology
- Infectious Diseases
- Pathophysiology
Background:
- Coagulopathies are increasingly recognized in COVID-19 patients.
- The relationship between hemostatic disorders and disease severity requires further elucidation.
Purpose of the Study:
- To investigate the association between coagulopathies and the clinical course of COVID-19.
- To understand the hemostatic alterations in moderate to severe COVID-19.
Main Methods:
- Examined 255 patients with moderate and severe COVID-19.
- Assessed hypercoagulability, clotting tests, blood clot contraction, and platelet function.
- Correlated hemostatic parameters with systemic inflammation, disease severity, comorbidities, and mortality.
Main Results:
- Hypercoagulability correlated with inflammation, severity, comorbidities, and mortality.
- Impaired blood clot contraction was observed in approximately 50% of patients, linked to prothrombotic parameters.
- Prolonged clotting tests were associated with high C-reactive protein and antiphospholipid antibodies.
- Absence of consumption coagulopathy suggests predominant microthrombosis.
Conclusions:
- Hemostatic disorders, particularly hypercoagulability and impaired clot contraction, are significant in COVID-19.
- Monitoring hemostasis, including clot contraction kinetics, is crucial.
- Prophylaxis against thrombotic complications is warranted in COVID-19 patients.
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