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Partition coefficient ratios and tumour perfusion studied with 85mKr and 133Xe
J Heikkonen1, M Mäntylä, J Perkkiö
1Department of Radiotherapy and Oncology, University Central Hospital, Helsinki, Finland.
Nuklearmedizin. Nuclear Medicine
|December 1, 1987
Summary
This study measured regional blood flow in tumors using krypton and xenon. Krypton clearance showed higher perfusion rates than xenon, possibly due to its smaller molecular weight.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Oncology
Background:
- Assessing regional blood flow in malignant tumors is crucial for diagnosis and treatment.
- Non-invasive methods are needed to accurately quantify tumor perfusion.
Purpose of the Study:
- To measure and compare regional blood flow and partition coefficients of krypton (Kr) and xenon (Xe) in superficial malignant tumors.
- To evaluate the utility of the 85mKr- and 133Xe-clearance method for tumor perfusion assessment.
Main Methods:
- Simultaneous injection of 85mKr and 133Xe into 27 malignant tumor nodules in 22 patients.
- Utilized the clearance method with compartmental analysis to calculate blood perfusion.
- Fitted a two-exponential function to clearance curves to determine perfusion rates.
Main Results:
- Mean perfusion rate for Xe: 13 ± 10 ml/(100 g·min) (range 3–38).
- Mean perfusion rate for Kr: 19 ± 11 ml/(100 g·min) (range 5–45).
- Calculated partition coefficient of Kr was slightly lower than Xe, potentially due to molecular weight differences.
Conclusions:
- The 85mKr- and 133Xe-clearance method provides valuable data on regional tumor blood flow.
- Differences in perfusion rates between Kr and Xe may relate to their respective partition coefficients and molecular weights.
- Further research can refine the application of these radiotracers for improved tumor characterization.