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Updated: Oct 24, 2025

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases - A Mini Review
Lavinia Rech1, Peter P Rainer1,2
1Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Abstract:
Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. Recent studies show that also self-DNA may activate cGAS-STING, for instance, DNA released from nuclei or mitochondria during obesity or myocardial infarction. Here, we focus on emerging evidence describing the interaction of cGAS-STING with cardiovascular risk factors and disease. We also touch on translational therapeutic opportunities and potential further investigations.
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