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Updated: Oct 24, 2025

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
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The role of cGAS-STING signalling in liver diseases

Ruihan Chen1, Jiamin Du2, Hong Zhu2

  • 1Department of Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

JHEP Reports : Innovation in Hepatology
|August 12, 2021
PubMed

Keywords:
AIM2, absent in melanoma 2ALD, alcohol-related liver diseaseAPCs, antigen-presenting cellsCDNs, cyclic dinucleotidesDAMPs, damage-associated molecular patternsDCs, dendritic cellsER, endoplasmic reticulumGVHD, graft-versus-host diseaseHCC, hepatocellular carcinomaHSCs, hepatic stellate cellsIFN-I, type I interferonIL, interleukinIRF3, interferon regulatory factor 3IRI, ischaemia refusion injuryKCs, Kupffer cellsLSECs, liver sinusoidal endothelial cellsMHC, major histocompatibility complexNAFLD, non-alcoholic fatty liver diseaseNK cells, natural killer cellsNPCs, non-parenchymal cellsPAMPs, pathogen-associated molecular patternsPD-1, programmed cell death protein-1PD-L1, programmed cell death protein ligand-1PPRs, pattern recognition receptorsSAVI, STING-associated vasculopathy with onset in infancySTING, stimulator of interferon genesTBK1, TANK-binding kinase 1TGF-β1, transforming growth factor-β1TLR, Toll-like receptorTNF, tumour necrosis factorXRCC, X-ray repair cross complementingaHSCT, allogeneic haematopoietic stem cell transplantationcGAMP, cyclic guanosine monophosphate-adenosine monophosphatecGAS, cyclic guanosine monophosphate-adenosine monophosphate synthasecGAS-STING signallingdsDNA, double-strand DNAhepatocellular carcinomainnate immune responseliver injurymTOR, mammalian target of rapamycinmtDNA, mitochondrial DNAnonalcoholic fatty liver diseasesiRNA, small interfering RNAssRNA, single-stranded RNAviral hepatitis

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