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Related Experiment Video

Updated: Oct 24, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Functional connectivity changes in complex migraine aura: beyond the visual network.

Marcello Silvestro1,2, Alessandro Tessitore1,2, Federica Di Nardo2

  • 1Headache Center, Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.

European Journal of Neurology
|August 12, 2021
PubMed
Summary
This summary is machine-generated.

Complex migraine with aura (MwA) patients exhibit distinct brain connectivity patterns. Increased connectivity in visual and sensorimotor networks differentiates complex MwA from simple visual MwA, suggesting unique neural correlates for aura types.

Keywords:
complex aurainsulalingual gyrusmigraine with aurasensorimotor networkvisual network

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Migraine with aura (MwA) presents with diverse symptoms beyond visual disturbances, including somatosensory, dysphasic, or motor phenomena.
  • The heterogeneity of aura symptoms suggests potential differences in underlying neural mechanisms and brain network involvement.

Purpose of the Study:

  • To investigate if complex MwA patients exhibit altered functional connectivity within visual and sensorimotor networks compared to simple visual MwA patients.
  • To explore the neural correlates differentiating complex aura phenotypes from simpler visual aura presentations.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (RS-Fc) to compare brain connectivity.
  • Analyzed resting-state functional connectivity in visual and sensorimotor networks.

Main Results:

  • Complex MwA patients demonstrated significantly higher RS-Fc in the left lingual gyrus (visual network) and right anterior insula (sensorimotor network).
  • Elevated right anterior insula RS-Fc effectively distinguished complex MwA from simple visual MwA patients (AUC 0.83).

Conclusions:

  • Enhanced extrastriate RS-Fc may facilitate cortical spreading depression, underpinning simple visual aura.
  • Coexisting increased insula RS-Fc could enable propagation to sensorimotor regions, resulting in complex aura phenotypes.