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Updated: Oct 24, 2025

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
Published on: August 13, 2020
Ten Years of EWAS
Siyu Wei1,2, Junxian Tao1,2, Jing Xu1,2
1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Abstract:
Epigenome-wide association study (EWAS) has been applied to analyze DNA methylation variation in complex diseases for a decade, and epigenome as a research target has gradually become a hot topic of current studies. The DNA methylation microarrays, next-generation, and third-generation sequencing technologies have prepared a high-quality platform for EWAS. Here, the progress of EWAS research is reviewed, its contributions to clinical applications, and mainly describe the achievements of four typical diseases. Finally, the challenges encountered by EWAS and make bold predictions for its future development are presented.
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