Changes in ocular pulse amplitude and choroidal thickness in childhood obesity patients with and without insulin
Gözde Aksoy Aydemir1, Emre Aydemir1, Abdulvahit Asik2
1Ophthalmology Department, Adıyaman University Education and Research Hospital, Adıyaman, Turkey.
Insights
Childhood obesity is associated with decreased choroidal thickness (CT) and ocular pulse amplitude (OPA). Insulin resistance did not significantly affect these ocular parameters in obese children.
Area of Science:
- Ophthalmology
- Pediatrics
- Endocrinology
Background:
- Childhood obesity is a growing global health concern.
- Obesity is linked to various systemic complications, potentially affecting ocular health.
- Insulin resistance (IR) is a common comorbidity in childhood obesity.
Purpose of the Study:
- To compare choroidal thickness (CT) and ocular pulse amplitude (OPA) in children with obesity and insulin resistance (IR) versus those without IR.
- To investigate potential ocular changes associated with childhood obesity.
Main Methods:
- Prospective study comparing 73 obese children with 62 age- and gender-matched healthy controls.
- Obesity defined by BMI-SDS > 2 SD.
- Intraocular pressure (IOP) and OPA measured by dynamic contour tonometry.
- CT measured via enhanced depth imaging optical coherence tomography at three locations.
Main Results:
- Obese children had significantly lower mean IOP and OPA compared to controls (p < 0.001).
- Mean subfoveal CT was significantly reduced in obese children (350.50 ± 81.51 μm) versus controls (390.02 ± 71.50 μm, p = 0.003).
- No significant differences in CT, OPA, or IOP were found between obese children with and without IR (p > 0.005).
Conclusions:
- Childhood obesity is associated with significantly decreased ocular pulse amplitude and choroidal thickness.
- Insulin resistance status did not appear to influence these ocular parameters in the studied obese children.
- Further research is recommended to explore longitudinal changes and evaluate these findings in diverse populations.
Purpose:
To compare choroidal thickness (CT) and ocular pulse amplitude (OPA) in childhood obesity with insulin resistance (IR) and without IR.
Methods:
Seventy-three childhood obesity and 62 healthy children, who were both age-matched and gender-matched, comprised the study population in this prospective study. Obesity was determined as having a body mass index (BMI) - standard deviation (SD) score that was > 2 SD.Intraocular pressure (IOP) and OPA were measured using a dynamic contour tonometer. The CT measurements were performed using enhanced depth imaging optical coherence tomography at three locations, comprising at the fovea, at a position 500 µm nasal, and also at a position 500 µm temporal to the fovea.
Results:
Mean BMI value was 28.72 ± 4.85 in the patients with childhood obesity and 21.47 ± 1.14 in the control group. The mean IOP and OPA values were determined 15.90 ± 2.30 and 14.10 ± 2.16 mm Hg, 1.50 ± 0.28 and 1.74 ± 0.32 mm Hg in the patients with childhood obesity and the control group, respectively (p < 0.001, p < 0.001). The mean subfoveal CT value was 350.50 ± 81.51 μm in the eyes with childhood obesity and 390.02 ± 71.50 μm in those of the control group (p = 0.003). When the patient groups with and without IR were compared, no significant difference was found between CT, OPA and IOP values (p > 0.005).
Conclusions:
Our results showed that both OPA and CT values were significantly decreased in childhood obesity patients. We suggest further studies to verify longitudinal changes in OPA and CT, as also the evaluation of these parameters in other populations.
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