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Updated: Oct 24, 2025

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Published on: February 10, 2023
Recommendations for the diagnosis and management of vaccine-induced immune thrombotic thrombocytopenia
B F Jacobson1, E Schapkaitz, M Mer
1Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. elise.schapkaitz@nhls.ac.za.
Abstract:
There have recently been safety concerns regarding an increased risk of vaccine-induced immune thrombotic thrombocytopenia (VITT) following administration of SARS-CoV-2 adenoviral vector vaccines. The Southern African Society of Thrombosis and Haemostasis reviewed the emerging literature on this idiosyncratic complication. A draft document was produced and revised by consensus agreement by a panel of professionals from various specialties. The recommendations were adjudicated by independent international experts to avoid local bias. We present concise, practical guidelines for the clinical management of VITT.
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