Considerations for COVID-19 vaccination in pregnancy

Area of Science:

• Obstetrics and Gynecology
• Infectious Diseases
• Vaccinology

Background:

• Pregnant individuals exhibit increased susceptibility to severe COVID-19 outcomes.
• Limited safety data exists for COVID-19 vaccines in pregnancy.
• Antenatal vaccination for influenza and pertussis demonstrates maternal and infant health benefits.

Purpose of the Study:

• To examine the role and safety of COVID-19 vaccination in pregnant women.
• To review available data on COVID-19 vaccines during pregnancy.
• To summarize current international recommendations and guidelines.

Main Methods:

• Literature review of studies on COVID-19 in pregnancy.
• Analysis of available safety and efficacy data for COVID-19 vaccines in pregnant populations.
• Synthesis of international society guidelines regarding antenatal COVID-19 vaccination.

Main Results:

• Pregnant women are at elevated risk for severe COVID-19 illness.
• International bodies recommend COVID-19 vaccination for pregnant women, particularly those at high risk.
• Vaccines are generally not advised against unless specific contraindications exist.

Conclusions:

• COVID-19 vaccination is a critical consideration for pregnant women due to increased health risks.
• Current guidelines support the use of COVID-19 vaccines in pregnancy, acknowledging limited but growing safety data.
• Antenatal vaccination strategies can potentially improve maternal and infant health outcomes.