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Clinical features and etiological analysis for 157 cases of pyogenic liver abscess

Jinqing Liu1, Yao Liu1, Chunhui Li2

  • 1Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|August 12, 2021
PubMed
Abstract

Insights

Multidrug-resistant pyogenic liver abscess (MDR-PLA) is linked to specific risk factors. Hepatolithiasis and biliary tract operations increase MDR-PLA risk, necessitating targeted interventions for pyogenic liver abscess (PLA) patients.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Microbiology

Background:

  • Pyogenic liver abscess (PLA) is a serious intra-abdominal infection.
  • The rise of multidrug-resistant (MDR) pathogens complicates PLA treatment.
  • Identifying risk factors for MDR-PLA is crucial for effective therapeutic strategies.

Purpose of the Study:

  • To investigate the clinical characteristics of PLA patients.
  • To identify the causative pathogens in PLA.
  • To determine risk factors associated with multidrug-resistant PLA (MDR-PLA).

Main Methods:

  • Retrospective review of 157 PLA patients with antibiotic susceptibility testing.
  • Classification into MDR-PLA (n=52) and non-MDR-PLA (n=107) groups.
  • Logistic regression analysis to identify risk factors for MDR-PLA.

Main Results:

  • Anorexia and abdominal pain were more prevalent in the MDR-PLA group.
  • Hepatolithiasis and prior biliary tract operations were significantly higher in MDR-PLA patients.
  • Klebsiella pneumoniae was the most common pathogen; Escherichia coli and Enterococcus showed lower drug sensitivity and higher MDR rates.

Conclusions:

  • Hepatolithiasis and biliary tract operations are significant risk factors for MDR-PLA.
  • Patients with these conditions and infections caused by Escherichia coli or Enterococcus require heightened vigilance for MDR bacterial infections.
  • Early identification and targeted antibiotic therapy are essential for managing MDR-PLA.
Keywords:
clinical featuresmultidrug resistancepyogenic liver abscessrisk factors

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