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Research progress in lncRNA and its action as ceRNA in ovarian function as well as the relevant diseases

Yuling Li1, Jie Chen2, Qianqian Luo1

  • 1Department of Gynecology of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|August 12, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate gene expression and ovarian function. These molecules form regulatory networks with microRNAs (miRNAs) and mRNAs, offering potential diagnostic and therapeutic targets for reproductive disorders.

Area of Science:

  • Molecular Biology
  • Reproductive Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression, influencing transcription, post-transcriptional modification, and epigenetic processes.
  • lncRNAs play a crucial role in maintaining normal ovarian physiological function.
  • Dysregulation of lncRNAs is implicated in the development of ovarian reproductive disorders.

Purpose of the Study:

  • To elucidate the role of lncRNAs in ovarian physiology and reproductive disorders.
  • To explore the lncRNA/microRNA (miRNA)/messenger RNA (mRNA) regulatory network in the ovary.
  • To identify lncRNAs as potential diagnostic markers and therapeutic targets for ovarian diseases.

Main Methods:

  • Investigated the regulatory mechanisms of lncRNAs in ovarian gene expression.
  • Analyzed the competitive endogenous RNA (ceRNA) activity of lncRNAs, focusing on their interaction with miRNAs.
  • Examined the lncRNA/miRNA/mRNA regulatory network's involvement in ovarian function and disorders.

Main Results:

  • lncRNAs significantly impact ovarian physiological functions through various regulatory pathways.
  • The lncRNA/miRNA/mRNA network is critical for maintaining ovarian homeostasis.
  • Alterations in this network are associated with the pathogenesis of ovarian reproductive disorders.

Conclusions:

  • lncRNAs are integral to ovarian function and reproductive health.
  • The lncRNA/miRNA/mRNA regulatory network represents a significant area for understanding ovarian disorders.
  • lncRNAs show promise as novel diagnostic indices and therapeutic targets for treating reproductive disorders.
Keywords:
competing endogenous RNAlong non-coding RNAovarian function

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