[Use of glipizide and evaluation of its effect on microcirculation in patients with diabetes mellitus type 2]

The paper is concerned with the assessment of glipizide action in 32 patients aged 34 to 68 suffering from diabetes mellitus with decompensation of metabolic processes. Good tolerance of the drug, its positive hypoglycemic action enhanced by its combined use with acetylsalicylic acid were noted. No convincing proofs of glipizide influence on microcirculatory indices were obtained. In comparing its hemorheological action with other sulfanilurea drugs of the 2nd generation a similar effect of glipizide with manilin as monotherapy was revealed, on the one hand, and, on the other hand, similar action of glipizide with acetylsalicylic acid and diamicron was noted.