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Related Concept Videos

Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Related Experiment Video

Updated: Oct 24, 2025

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
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Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors.

Benjamin R Kingston1,2, Zachary P Lin1,2, Ben Ouyang1,2,3

  • 1Institute of Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

ACS Nano
|August 12, 2021
PubMed
Summary
This summary is machine-generated.

Researchers discovered nanoparticle transport endothelial cells (N-TECs) that control nanoparticle entry into solid tumors. These specialized cells regulate nanoparticle delivery, distribution, and accessibility within the tumor microenvironment.

Keywords:
blood vesselscancerdrug deliveryendothelial cellsimage analysisnanoparticles

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Area of Science:

  • Biomedical Engineering
  • Cancer Biology
  • Nanotechnology

Background:

  • Effective nanoparticle delivery to solid tumors is crucial for therapeutic success.
  • Nanoparticle transport across tumor vasculature remains a significant challenge in drug delivery.

Purpose of the Study:

  • To identify specific endothelial cell populations involved in nanoparticle transport into solid tumors.
  • To characterize the unique properties of these facilitating endothelial cells.

Main Methods:

  • Utilized advanced imaging techniques to observe nanoparticle behavior within tumor vasculature.
  • Performed gene expression analysis on identified endothelial cell subsets.
  • Quantified the percentage of endothelial cells involved in nanoparticle transport.

Main Results:

  • Discovered a distinct subset of tumor endothelial cells, termed nanoparticle transport endothelial cells (N-TECs).
  • N-TECs constitute approximately 21% of tumor endothelial cells, located on a limited number of vessels.
  • N-TECs exhibit elevated expression of genes associated with nanoparticle transport and increased vessel permeability.
  • N-TECs function as critical gatekeepers, governing nanoparticle entry, distribution, and accessibility.

Conclusions:

  • N-TECs play a pivotal role in regulating nanoparticle delivery into solid tumors.
  • Targeting N-TECs could enhance nanoparticle-based cancer therapies.
  • Understanding N-TEC function is key to optimizing nanoparticle drug delivery strategies.