Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

76.3K
Overview
76.3K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

15.4K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
15.4K
Genetic Screens02:46

Genetic Screens

5.2K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.2K
Gene Therapy00:59

Gene Therapy

26.2K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
26.2K
CRISPR01:59

CRISPR

53.6K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
53.6K
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

709
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
709

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Target product profiles of laboratory and data analytical frameworks for genotyping to monitor antimalarial efficacy.

PLOS global public health·2026
Same author

Global-scale population genetic analysis of Plasmodium falciparum identifies region-specific patterns of malaria parasite adaptation.

Nature communications·2026
Same author

Rapid whole-genome sequencing of Plasmodium DNA from cryptic malaria cases in UK travellers provides insights into infection origins, transmission and antimalarial resistance.

Journal of travel medicine·2026
Same author

Novel <i>Pfk13</i> and <i>Pfubp1</i> genotypes in African <i>Plasmodium falciparum</i> isolates exhibiting reduced susceptibility to the antimalarials artemisinin and lumefantrine.

mBio·2026
Same author

A Systematic Review of Alternative Artemisinin Production Strategies.

International journal of molecular sciences·2025
Same author

Epigenetically conferred ring-stage survival in Plasmodium falciparum against artemisinin treatment.

Nature communications·2025
Same journal

SqueakPose Studio, an end-to-end platform for pose estimation and real-time edge-AI deployment.

eLife·2026
Same journal

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival.

eLife·2026
Same journal

Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode.

eLife·2026
Same journal

Lipid packing contributes to the confinement of caveolae to the plasma membrane.

eLife·2026
Same journal

A coma pattern-based autofocusing method resolves bacterial cold shock response at single-cell level.

eLife·2026
Same journal

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy.

eLife·2026
See all related articles

Related Experiment Video

Updated: Oct 24, 2025

Generation of Genetically Modified Mice through the Microinjection of Oocytes
10:19

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

21.1K

A genetic intervention.

Colin Sutherland1, Didier Menard2,3

  • 1Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Elife
|August 12, 2021
PubMed
Summary
This summary is machine-generated.

A new genomic tool aids in understanding drug-resistant malaria parasites in patients. This analysis can guide public health policies to combat rising resistance effectively.

Keywords:
AsiaP. falciparumdrug resistanceepidemiologygenetic surveillanceglobal healthinfectious diseasemalariamicrobiology

More Related Videos

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
09:37

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

Published on: March 5, 2017

13.3K
Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
09:04

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells

Published on: September 25, 2019

8.4K

Related Experiment Videos

Last Updated: Oct 24, 2025

Generation of Genetically Modified Mice through the Microinjection of Oocytes
10:19

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

21.1K
Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
09:37

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

Published on: March 5, 2017

13.3K
Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
09:04

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells

Published on: September 25, 2019

8.4K

Area of Science:

  • Genomics
  • Parasitology
  • Public Health

Background:

  • Malaria remains a significant global health challenge.
  • The emergence of drug-resistant malaria parasites poses a serious threat to disease control efforts.

Purpose of the Study:

  • To introduce a novel genomic analysis tool for malaria parasites.
  • To support evidence-based policy decisions for combating drug resistance.

Main Methods:

  • Genome sequencing of malaria parasites from patient blood samples.
  • Bioinformatic analysis to identify genetic markers of drug resistance.

Main Results:

  • The tool successfully analyzes parasite genomes.
  • Identified genetic patterns associated with resistance to antimalarial drugs.

Conclusions:

  • Genomic analysis of malaria parasites is crucial for tracking and managing drug resistance.
  • This tool can inform targeted interventions and policy development.