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Updated: Oct 24, 2025

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
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[How does COVID-19 affect intestinal microbiota?]

Peter C Konturek1

  • 1Klinik für Innere Med. II/Saalfeld, Thüringen-Kliniken "Georgius Agricola" GmbH, Rainweg 68, 07318, Saalfeld, Germany. pkonturek@web.de.

MMW Fortschritte Der Medizin
|August 12, 2021
PubMed
Summary
This summary is machine-generated.

The gut microbiome influences the immune response to SARS-CoV-2. COVID-19 can cause gut dysbiosis, potentially worsening the cytokine storm, but prebiotics and probiotics may enhance immune defenses.

Keywords:
COVID-19Lung-intestinal axiscytokine stormintestinal microbiotaprobiotics

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Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • The lung-intestinal axis describes the bidirectional communication between the gut and lungs.
  • The gut microbiome plays a crucial role in modulating systemic immunity.

Purpose of the Study:

  • To review the influence of intestinal microbiota on immune responses during SARS-CoV-2 infection.
  • To explore the link between gut dysbiosis and COVID-19 severity.

Main Methods:

  • Literature review of studies investigating the gut microbiome and SARS-CoV-2.
  • Analysis of research on the impact of dysbiosis on immune responses.

Main Results:

  • COVID-19 is associated with gut dysbiosis, which can persist post-infection.
  • Intestinal microbiota composition correlates with COVID-19 severity.
  • Dysbiosis may contribute to the cytokine storm observed in severe COVID-19.

Conclusions:

  • Modulating the gut microbiome may be a therapeutic strategy for COVID-19.
  • Prebiotics and probiotics show potential in bolstering immune responses in both the gut and lungs.