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[Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic
1Sektion Biowissenschaften, Karl-Marx-Universität Leipzig.
Die Pharmazie
|November 1, 1987
Abstract:
Structural analogues of platelet-activating factor (PAF, 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine) containing an imidazole or thiazole residue as polar head group have been prepared and tested for platelet aggregating properties. Compared with PAF all analogues exert considerably lower platelet-stimulating activities. The agonistic behaviour is shown to depend primary on the presence of a positively charged polar head group.