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Published on: December 15, 2014
Cardiovascular characteristics of patients initially diagnosed breast cancer
Zhaoying Dong1, Fan Zhang2, Qiaojuan Huang1
1Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400000, China.
Insights
Postmenopausal women with breast cancer have increased cardiovascular risk factors and higher arteriosclerotic cardiovascular disease (ASCVD) risk. Cardiovascular risk factors are correlated with axillary lymph node metastasis (ALNM) in these patients.
Area of Science:
- Cardiology
- Oncology
- Epidemiology
Background:
- Breast cancer diagnosis impacts cardiovascular health.
- Understanding cardiovascular risk factors (CVRFs) in breast cancer patients is crucial for comprehensive care.
Purpose of the Study:
- To investigate the cardiovascular characteristics of patients diagnosed with breast cancer.
- To identify cardiovascular risk factors (CVRFs) and their association with axillary lymph node metastasis (ALNM) in breast cancer patients.
Main Methods:
- Retrospective study of 600 primary breast cancer patients.
- Collected data on blood glucose, lipids, lipoprotein (a) (LP (a)), and uric acid.
- Utilized univariate and multivariate analyses for CVRFs and ALNM assessment, including arteriosclerotic cardiovascular disease (ASCVD) risk stratification.
Main Results:
- Postmenopausal breast cancer patients exhibited higher prevalence of overweight/obesity, diabetes, and hypertension compared to premenopausal patients.
- Significant differences in ASCVD risk stratification were observed between postmenopausal and premenopausal groups.
- Residence, number of children, and LP (a) levels showed potential correlation with ALNM.
Conclusions:
- Postmenopausal status is associated with increased CVRFs and ASCVD risk in breast cancer patients.
- A correlation exists between CVRFs and ALNM in breast cancer patients, highlighting the need for integrated cardiovascular and oncological management.
Objective:
We aimed to explore the cardiovascular characteristics of patients who were initially diagnosed with breast cancer.
Methods:
A total of 600 patients who were diagnosed with primary breast cancer were included in this retrospective study. The data of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, lipoprotein (a) (LP (a)) and serum uric acid were collected. Univariate analysis was used to evaluate the cardiovascular risk factors (CVRFs) in patients with breast cancer. The arteriosclerotic cardiovascular disease (ASCVD) risk assessment was performed. Multivariate analysis was used to identify the factors that influenced axillary lymph node metastasis (ALNM).
Results:
Compared with the premenopausal group, the prevalence of overweight/obesity (47.6% vs. 35.2%), diabetes (12.8% vs. 4.3%) and hypertension (49.7% vs. 26.3%) were significantly increased in the postmenopausal group (p < 0.05). Comparisons of rural patients and urban patients showed that there were significant differences in the diagnostic age (49.94 ± 9.92 vs. 52.59 ± 11.13) in the rural patients was notably younger in comparison with the urban patients (p < 0.05). However, the number of menopausal patients (44.3% vs. 53.3%) in the rural group were decreased in comparison with the urban group (p < 0.05). In ASCVD risk stratification, the proportion of low-risk patients (56.4% vs. 90.8%), medium-risk patients (20.6% vs 0.3%) and high-risk patients (19.3% vs. 6.6%) were significantly different between the postmenopausal group and premenopausal group (p < 0.05). Residence (OR 0.735; 95% CI 0.516-1.046; p = 0.087), the number of children (OR 1.250; 95% CI 0.990-1.578; p = 0.061) and LP (a) of ≥ 500 mg/L (OR 0.603; 95% CI 0.342-1.063; p = 0.080) were independent influencing factors of ALNM.
Conclusion:
Postmenopausal patients have more CVRFs and higher risks of ASCVD than premenopausal patients initially diagnosed with breast cancer. There was a correlation between CVRFs and ALNM in patients with breast cancer.
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