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Nosocomial COVID-19. Prospective study in a referral hospital
Laura Escolà-Vergé1, Blanca Borràs-Bermejo2, Ibai Los-Arcos1
1Servicio de Enfermedades Infecciosas, Hospital Universitari Vall d'Hebron, Barcelona, España; Red Española para la Investigación en Enfermedades Infecciosas (REIPI RD16/0016/0003), Instituto de Salud Carlos III, Madrid, España.
Background And Objective:
The objective was to describe the clinical characteristics and prognosis of patients with nosocomial SARS-CoV-2 infection.
Methods:
An observational and prospective study was performed in a referral hospital. We included all adult patients diagnosed with nosocomial SARS-CoV-2 infection in October 2020. Nosocomial infection was defined as a negative PCR for SARS-CoV-2 on admission and a positive PCR after 7 days of hospitalization.
Results:
We included 66 cases of nosocomial SARS-CoV-2 infection: 39 (59%) men, median age at diagnosis was 74.5 years (IQR 56.8-83.1) and median Charlson comorbidity index was 3 points (IQR 1-5). Twenty-seven (41%) developed pneumonia and 13 (20%) died during admission. Mortality at 28 days was 33% (22 patients). Mortality at 28 days in the 242 patients with community-acquired SARS-CoV-2 infection who were hospitalized during the same period was 10%.
Conclusions:
Preventive measures and early detection of nosocomial outbreaks of COVID-19 should be prioritized to minimize the negative impact of this infection.
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