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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Perspectives on Heyde's Syndrome and Calcific Aortic Valve Disease

Ramy Abdelmaseih1, Ravi Thakker2, Randa Abdelmasih1

  • 1University of Central Florida College of Medicine, Graduate Medical Education, Orlando, FL; Department of Internal Medicine, HCA/Ocala Regional Medical Center, Ocala, FL.

Current Problems in Cardiology
|August 13, 2021
PubMed

Insights

Heyde's syndrome links calcified aortic stenosis, gastrointestinal bleeding from arteriovenous malformations, and von Willebrand syndrome. This review highlights diagnosis and management of this rare condition, particularly in the elderly.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Hematology

Background:

  • Heyde's syndrome is a rare multisystem disorder.
  • It involves calcified aortic stenosis, GI bleeding from arteriovenous malformations (AVMs), and acquired von Willebrand syndrome (AVWS).

Observation:

  • The association between aortic stenosis and GI AVMs is noted, but the incidence of Heyde's syndrome is debated.
  • The condition is more prevalent in the elderly population.

Findings:

  • This review presents a case study to illustrate the diagnosis and management of Heyde's syndrome.
  • It also provides a general overview of calcific aortic valve disease (CAVD) prevalence, etiology, diagnosis, and management.

Implications:

  • Highlights the importance of recognizing Heyde's syndrome in elderly patients with relevant symptoms.
  • Emphasizes the need for further research into the controversial pathogenesis and management strategies.
  • Provides a comprehensive resource for clinicians managing patients with CAVD and associated GI bleeding.

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