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Updated: Oct 24, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Migraine with aura.

C Lucas1

  • 1Centre d'evaluation et de traitement de la douleur, service de neurochirurgie, hôpital Salengro, CHU de Lille, 59037 Lille Cedex, France.

Revue Neurologique
|August 13, 2021
PubMed
Summary
This summary is machine-generated.

Migraine aura involves temporary neurological symptoms like visual disturbances, often preceding headaches. Early treatment with NSAIDs or aspirin can help manage the headache phase, while stroke risk is elevated in migraine with aura patients.

Keywords:
AuraCortical spreading depressionMigraine

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Area of Science:

  • Neurology
  • Neuroscience
  • Headache Medicine

Background:

  • Migraine with aura affects 15-33% of migraineurs, characterized by reversible neurological symptoms.
  • Cortical spreading depression (CSD) is the primary proposed mechanism underlying migraine aura.
  • Diagnosis relies on the International Headache Classification Disorders III criteria, emphasizing gradual onset and symptom duration.

Purpose of the Study:

  • To provide a comprehensive overview of migraine aura, including its mechanisms, diagnosis, and management.
  • To highlight the diagnostic challenges and differential diagnoses for aura symptoms.
  • To discuss the increased risk of ischemic stroke associated with migraine with aura and management strategies.

Main Methods:

  • Review of existing literature on migraine aura, cortical spreading depression, and associated risks.
  • Analysis of diagnostic criteria from the International Headache Classification Disorders III.
  • Examination of treatment guidelines for acute and prophylactic management of migraine with aura.

Main Results:

  • Aura symptoms are typically visual, sensory, speech, or motor, developing gradually and lasting up to an hour.
  • Visual aura is the most common type, occurring in over 90% of cases.
  • Migraine with aura significantly increases the relative risk of ischemic stroke, particularly with estrogen-containing hormonal contraception.

Conclusions:

  • Prompt initiation of NSAIDs or aspirin during the aura phase may mitigate the subsequent headache.
  • Triptans are recommended for headache management if NSAIDs/aspirin fail.
  • Prophylactic treatments for migraine with aura largely mirror those for migraine without aura due to limited specific trials.