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Stevens-Johnson syndrome post second dose of Pfizer COVID-19 vaccine: a case report

Mohamed Omar Elboraey1, Emad El Said Fahim Essa2

  • 1Lecturer of Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Tanta University, Tanta, Egypt; Assistant Professor of Periodontology Department, College of Dentistry, Taibah University, Al Medinah, Kingdom of Saudi Arabia.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
|August 13, 2021
PubMed

Insights

The Pfizer COVID-19 vaccine is generally safe and effective, reducing severe illness. A rare case of Stevens-Johnson syndrome (SJS) occurred after vaccination, but the patient fully recovered, highlighting vaccine benefits outweighing risks.

Area of Science:

  • Immunology
  • Vaccinology
  • Dermatology

Background:

  • Coronavirus disease 2019 (COVID-19) presents with severe respiratory illness, multiorgan failure, and death.
  • COVID-19 vaccines are crucial for reducing morbidity and mortality, demonstrating good tolerability.
  • No specific antiviral therapies exist for COVID-19 infection.

Observation:

  • A case of Stevens-Johnson syndrome (SJS), a severe skin reaction, is reported following the second dose of the Pfizer COVID-19 vaccine.
  • The patient had no other drug exposure preceding the adverse reaction.
  • The patient experienced a complete recovery from the severe adverse event.

Findings:

  • Stevens-Johnson syndrome (SJS) is a potential, albeit rare, complication associated with COVID-19 vaccination.
  • The reported case of SJS following Pfizer vaccination resolved fully.
  • The study underscores the rarity of SJS in the context of COVID-19 vaccination.

Implications:

  • The findings reinforce that the benefits of COVID-19 vaccination significantly outweigh the potential risks, including rare adverse events like SJS.
  • This case contributes to the understanding of vaccine safety profiles and post-vaccination adverse events.
  • Continued monitoring and reporting of vaccine side effects are essential for public health and vaccine confidence.

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