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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Interactions Between Signaling Pathways01:19

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Overview of Cell-Matrix Interactions01:24

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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A Proximal Culture Method to Study Paracrine Signaling Between Cells
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Pericytes cross-talks within the tumor microenvironment.

Caroline C Picoli1, Bryan Ô P Gonçalves1, Gabryella S P Santos1

  • 1Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Biochimica Et Biophysica Acta. Reviews on Cancer
|August 13, 2021
PubMed
Summary

Pericytes communicate with cancer cells within the tumor microenvironment. Understanding these interactions is key for developing new cancer therapies.

Keywords:
Genetic depletionMetastatic nichePericytesTumor microenvironmentβ3 integrin

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Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Tumor progression involves dynamic interactions between cancer cells and the tumor microenvironment.
  • Molecular communication within the tumor microenvironment is critical for therapeutic success.

Purpose of the Study:

  • To review recent advancements in understanding the roles of pericytes in tumors.
  • To highlight the communication mechanisms between pericytes and cancer cells.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies utilizing advanced technologies like in vivo inducible Cre/loxP systems and CRISPR-Cas9 gene editing.

Main Results:

  • Evidence demonstrates communication between pericytes and cancer cells.
  • State-of-the-art technologies are revealing these intricate cellular cross-talks.

Conclusions:

  • Knowledge of tumor microenvironment cross-talks, particularly involving pericytes, is essential for novel cancer therapy development.
  • Further research into pericyte-cancer cell communication will drive therapeutic innovation.