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Published on: November 24, 2020
Arsenic and weight loss: At a crossroad between lipogenesis and lipolysis
Somayeh Handali1, Mohsen Rezaei2
1Medical Biomaterial Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
Arsenic is found in soil, food, water and earth crust. Arsenic exposure is associated with chronic diseases such as cancer, cardiovascular disease as well as diabetes. One of complex effects of arsenic is on weight gain or loss. Involvement of arsenic in both weight loss and gain signaling pathways has previously been reported; however, too little attention has been paid to its weight reducing effect. Animal studies exhibited a role of arsenic in weight loss. In this regard, arsenic interference with endocrine system, leptin and adiponectin hormones as well as thermogenesis is more evidence. Apparently, arsenic-induced weight lossis generally meditated by its interaction with thermogenesis. In this review we have discussed the irregularities in metabolic pathways induced by arsenic that can lead to weight loss.
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