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Heritability and interindividual variability of regional structure-function coupling.

Zijin Gu1, Keith Wakefield Jamison2, Mert Rory Sabuncu1,2

  • 1School of Electrical and Computer Engineering, Cornell University, Ithaca, NY, USA.

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Summary
This summary is machine-generated.

This study reveals that the connection between brain structure and function varies by region and is influenced by genetics. These individual differences in structural-functional connectivity coupling offer insights into brain organization.

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Human Connectomics

Background:

  • White matter structural connections are hypothesized to support functional activation and connectivity.
  • Previous research on structural-functional connectivity (SC-FC) coupling primarily focused on global brain levels, with limited regional analysis.

Purpose of the Study:

  • To quantify regional SC-FC coupling in healthy adults.
  • To investigate the heritability and individual variability of regional SC-FC coupling.
  • To explore relationships between regional SC-FC coupling and demographic/cognitive factors.

Main Methods:

  • Utilized diffusion-weighted MRI and resting-state functional MRI data from the Human Connectome Project.
  • Quantified SC-FC coupling at a regional scale across the brain.
  • Analyzed variations based on age, sex, cognitive scores, and heritability within networks.

Main Results:

  • Regional SC-FC coupling strength exhibited significant variation across brain regions.
  • Strongest SC-FC coupling was observed in visually and subcortically connected areas.
  • SC-FC coupling showed interindividual differences related to age, sex, and cognitive performance, and was highly heritable within specific brain networks.

Conclusions:

  • Regional SC-FC coupling is a distinct characteristic of individual brain organization.
  • Genetic factors significantly influence regional structure-function coupling.
  • Understanding regional SC-FC coupling provides insights into the idiosyncratic nature of brain architecture.