The effect of chronic digitalis therapy on the course of heart failure and on endocrine function in cardiomyopathic hamsters
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J E Ottenweller1, W N Tapp, B H Natelson
1Primate Neuro-behavioral Unit, VA Medical Center, East Orange NJ.
Research Communications in Chemical Pathology and Pharmacology
|December 1, 1987
Abstract:
Eleven month old cardiomyopathic hamsters, which have enlarged hearts and anasarca, were given access to either an ethanol vehicle or an ethanol-digoxin solution in addition to a second water bottle. In comparison to controls, treated hamsters survived and showed significant amelioration of the pathological syndrome of heart failure. Thus, in this model of advanced congestive failure, digoxin has a clear-cut beneficial effect.