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Updated: Oct 24, 2025
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Synthesis, characterization, and biological evaluation of new copper complexes of naphthyl pyrazole ligands
Melek Hinis1, Kuldip Singh2, Demet Erdönmez3
1Department of Chemistry, Faculty of Arts and Sciences, Aksaray University, Aksaray Turkey.
Abstract:
Two naphthalene pyrazole ligands were synthesized using KOH/DMSO and Cu catalyst and characterized with FT-IR, ESI-MS, 1H, and 13C NMR spectroscopies. The crystal structures of 1-(2-methylnaphthalen-1-yl)-1H-pyrazole (MeNap-Pz) ligand have been determined with X-ray crystal structure analysis. Reaction of the ligands with Cu(NO3)2x3.5H2O gave two new complexes and characterized with magnetic susceptibility, molar conductance, FT-IR, LCMS-MS, ICP-OES, NMR, thermogravimetric analysis, and ESR spectra. The spectral data of the ligands are coordinated to the metal ion through the nitrogen atoms of the pyrazole ring. Consequently, it has been determined that [Cu(MeNap-Pz)2(NO3)]NO3.2H2O complex showed square planar geometry and [Cu(NapMe-Pz)2(NO3)2].H2O complex showed octahedral geometry. All compounds were screened for in vitro antibacterial activity and copper complexes have been shown to be effective on bacteria.
