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Clinical outcomes of atrial fibrillation with hyperthyroidism

Muhammad Zubair Khan1, Ashwani Gupta2, Jordesha Hodge1

  • 1Department of Internal Medicine St. Mary Medical Center Langhorne PA USA.

Journal of Arrhythmia
|August 13, 2021
PubMed

Insights

Patients with atrial fibrillation (Afib) and hyperthyroidism experienced better clinical outcomes, including lower mortality and hospitalization costs. This study highlights the improved prognosis for Afib patients with co-existing hyperthyroidism.

Area of Science:

  • Cardiology
  • Endocrinology
  • Health Outcomes Research

Background:

  • Atrial fibrillation (Afib) is a frequent cardiac complication of hyperthyroidism.
  • Limited data exist on the clinical outcomes of patients with Afib, particularly concerning the influence of hyperthyroidism.

Purpose of the Study:

  • To investigate the clinical outcomes of patients diagnosed with Afib and hyperthyroidism compared to those with Afib alone.
  • To test the hypothesis that co-existing hyperthyroidism improves clinical outcomes in Afib patients.

Main Methods:

  • Utilized the National Inpatient Sample database (2015-2017) with validated ICD-10-CM codes for Afib and hyperthyroidism.
  • Stratified patients into two groups: Afib with hyperthyroidism and Afib without hyperthyroidism.
  • Employed multivariate regression analysis to adjust for confounding factors.

Main Results:

  • Identified 9,727,295 Afib patients; 90,635 (0.9%) had hyperthyroidism. Hyperthyroidism prevalence was higher in Afib patients (0.9% vs. 0.4%, P < .001).
  • Afib patients with hyperthyroidism were younger, more likely female, and had lower prevalence of comorbidities like CAD, cardiomyopathy, and hypertension.
  • These patients exhibited lower hospitalization costs, shorter length of stay, and reduced in-hospital mortality (3.3% vs. 4.8%, P < .001), with a higher discharge rate to home (51% vs. 42%, P < .001).

Conclusions:

  • Hyperthyroidism is significantly associated with Afib in both univariate and multivariate analyses.
  • Afib patients with hyperthyroidism demonstrate demonstrably better clinical outcomes compared to Afib patients without hyperthyroidism.
Abstract

Keywords:
arrhythmiaatrial fibrillationhyperthyroidism

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