Related Experiment Video

Updated: Oct 24, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.1K

Low-carb Diet in Hospitalized Late Pubertal Type 1 Diabetic Girls: A Short-Term CGM Study

Nefise Aribas Öz1,2, Ilknur Arslanoglu3, Sengül Cangür4

  • 1Department of Pediatrics, Faculty of Medicine, Duzce University, Konuralp, Duzce, Turkey.

Indian Journal of Endocrinology and Metabolism
|August 13, 2021
PubMed

Insights

A low-carb diet (LCD) in girls with type 1 diabetes improved glycemic control and reduced insulin needs without adverse effects. This suggests potential benefits for weight management and atherosclerosis prevention.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Pediatric Diabetes

Background:

  • Type 1 diabetes management requires careful balancing of diet, insulin, and physical activity.
  • Glycemic control is crucial for preventing long-term complications.
  • Dietary interventions, such as low-carbohydrate diets (LCDs), are increasingly explored for their impact on diabetes management.

Purpose of the Study:

  • To evaluate the short-term benefits and risks of a low-carbohydrate diet (LCD) in girls with type 1 diabetes.
  • To assess the impact of LCD on glycemic control and insulin requirements.

Main Methods:

  • A prospective randomized cross-over study involving 28 girls with type 1 diabetes.
  • Participants were hospitalized for 7-day periods, alternating between an LCD and a regular diet.
  • Continuous glucose monitoring (CGM) was used to assess glycemic control throughout the study.

Main Results:

  • The low-carbohydrate diet (LCD) was associated with significantly lower carbohydrate intake and reduced rapidly acting insulin doses.
  • Morning postprandial, noon postprandial, and evening preprandial blood glucose levels were significantly lower on the LCD.
  • No adverse events were reported during the study period.

Conclusions:

  • The low-carbohydrate diet (LCD) demonstrated potential for improved glycemic control in girls with type 1 diabetes.
  • Lower insulin requirements on LCD may offer advantages for weight control and atherosclerosis prevention.
  • LCD appears to be a safe short-term dietary strategy for this population.
Abstract

Keywords:
Continuous glucose monitoringdietlow carbohydratepubertytype 1 diabetes

More Related Videos

Simple Continuous Glucose Monitoring in Freely Moving Mice03:25

Simple Continuous Glucose Monitoring in Freely Moving Mice

Published on: February 24, 2023

6.5K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

69.8K

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
327
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
474
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.5K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.3K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
12.7K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.3K