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Related Experiment Video

Updated: Oct 24, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Understanding Host-Pathogen Interactions in Acute Chorioamnionitis Through the Use of Animal Models.

Amanda Brosius Lutz1, Salwan Al-Nasiry2, Boris W Kramer3

  • 1Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Frontiers in Cellular and Infection Microbiology
|August 13, 2021
PubMed
Summary

Chorioamnionitis, an inflammation during pregnancy, contributes to 40% of preterm births. This review evaluates animal models for studying chorioamnionitis pathogenesis and developing new therapies.

Keywords:
animal modelschorioamnionitishost-pathogen interactionpregnancypreterm birth

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Translational Medicine

Background:

  • Chorioamnionitis, inflammation of the fetal membranes, is a significant complication of pregnancy.
  • It is implicated in approximately 40% of preterm births, posing risks to mother, fetus, and newborn.
  • The high disease burden and limited therapeutic options necessitate research into novel treatment strategies.

Purpose of the Study:

  • To review the key features of human chorioamnionitis.
  • To evaluate existing animal models for their utility in studying chorioamnionitis.
  • To guide the application of these models in addressing critical research questions.

Main Methods:

  • Review of human chorioamnionitis characteristics.
  • Evaluation of animal models (mice, rabbits, sheep, non-human primates) for chorioamnionitis research.
  • Analysis of model relevance to human disease features and host-pathogen interactions.

Main Results:

  • Various animal models exist, each offering unique approaches to induce inflammation and study consequences.
  • Models differ in their ability to recapitulate specific aspects of human chorioamnionitis.
  • The choice of model impacts the ability to investigate host-pathogen interactions and disease mechanisms.

Conclusions:

  • Animal models are crucial for understanding chorioamnionitis pathogenesis and developing therapies.
  • Careful selection and application of appropriate models are essential for advancing research.
  • Further research is needed to optimize existing models and develop new ones to better mimic human disease.