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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review

Fan Chao1, Shiyu Wang1, Cong Zhang1

  • 1Department of Urology, Jinshan Hospital, Fudan University, Shanghai, China.

Frontiers in Cell and Developmental Biology
|August 13, 2021
PubMed

Insights

Circular RNAs (circRNAs) play a crucial role in prostate cancer progression, influencing tumor growth, metastasis, and drug resistance. Understanding these circRNAs offers potential for novel prostate cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer remains a significant health concern for men globally.
  • Aberrant expression of circular RNAs (circRNAs) is observed in various cancers, including prostate cancer.
  • CircRNAs are implicated in critical cancer hallmarks such as metastasis, proliferation, and drug resistance.

Approach:

  • A systematic literature review was conducted using PubMed and Web of Science databases.
  • Searched for publications on circRNAs and prostate cancer up to June 16, 2021.
  • Included 73 publications to summarize the biological roles of circRNAs in prostate cancer.

Key Points:

  • Dysregulated circRNAs impact prostate cancer cell cycle, proliferation, migration, invasion, and metastasis.
  • CircRNAs are involved in drug resistance and radiosensitivity in prostate cancer.
  • CircRNAs can function via extracellular vesicles (EVs) and serve as diagnostic and prognostic biomarkers.

Conclusions:

  • CircRNAs are implicated in the tumorigenesis and progression of prostate cancer.
  • Understanding circRNA mechanisms may lead to the development of new therapeutic strategies for prostate cancer.
  • Specific circRNAs correlate with clinicopathological features, highlighting their potential clinical relevance.
Keywords:
biomarkercircRNAmetastasisproliferationprostate cancer

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