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Updated: Oct 24, 2025

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

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The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases

Zhilei Wang1,2,3, Nian Chen3, Zhiyong Li3

  • 1TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in Cell and Developmental Biology
|August 13, 2021
PubMed

Insights

The cGAS-STING pathway is crucial for immune defense against liver diseases. Understanding its role and targeting it with drugs offers new therapeutic strategies for liver conditions.

Area of Science:

  • Immunology
  • Hepatology
  • Molecular Biology

Background:

  • Inflammation is a key immune response to harmful stimuli.
  • The cGAS-STING pathway acts as a critical sensor in host immunity, protecting against infections, metabolic disorders, and cancer.
  • Emerging research highlights the cGAS-STING pathway's significance in various liver diseases, including ischemia-reperfusion injury and viral hepatitis.

Purpose of the Study:

  • To review the intricate relationship between the cGAS-STING pathway and the development and progression of liver diseases.
  • To explore the potential of cGAS-STING signaling modulators as therapeutic agents for liver ailments.

Main Methods:

  • Literature review focusing on the cGAS-STING pathway's role in liver pathophysiology.
  • Analysis of existing and potential pharmacological interventions targeting cGAS-STING signaling.

Main Results:

  • The cGAS-STING pathway is implicated in the mechanisms underlying hepatic ischemia reperfusion injury, steatohepatitis, and viral hepatitis.
  • Pharmacological agonists and antagonists of cGAS-STING signaling represent promising avenues for novel liver disease treatments.

Conclusions:

  • A comprehensive understanding of the cGAS-STING pathway's biology is essential for advancing liver disease therapies.
  • Targeting the cGAS-STING pathway holds significant potential for developing innovative treatments for a range of liver conditions.
Keywords:
DNA-sensingcyclic GMP-AMP synthasecyclic guanosine monophosphate-adenosine monophosphateliver diseasesstimulator of interferon genes

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