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Published on: May 2, 2013
Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection
Amy C Sherman1, Xiaoyan Lu2, Eileen Schneider2
1Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Background:
Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection.
Methods:
Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed.
Results:
WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir.
Conclusions:
Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.
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