Related Experiment Video

Updated: Oct 24, 2025

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.1K

Cardiovascular Magnetic Resonance Reveals Cardiac Pathophysiology in Autoimmune Rheumatic Diseases

George Markousis-Mavrogenis1, Petros P Sfikakis2,3, Loukia Koutsogeorgopoulou3

  • 1Onassis Cardiac Surgery Center, Athens, Greece.

Mediterranean Journal of Rheumatology
|August 13, 2021
PubMed

Insights

Cardiovascular magnetic resonance (CMR) detects early cardiovascular disease (CVD) in autoimmune rheumatic diseases (ARDs), aiding personalized treatment. This imaging technique identifies inflammation and fibrosis, crucial for managing high-risk patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Autoimmune rheumatic diseases (ARDs) significantly increase cardiovascular disease (CVD) incidence and mortality.
  • Early detection of CVD in ARD patients is critical for improving outcomes.
  • Cardiovascular magnetic resonance (CMR) offers a non-invasive method for early CVD assessment in ARD.

Purpose of the Study:

  • To review the diagnostic capabilities of CMR in identifying CVD in ARD patients.
  • To highlight how CMR findings guide treatment decisions for ARD patients.
  • To summarize the role of CMR in the personalized management of ARD.

Main Methods:

  • Utilizing balanced steady-state free precession (bSSFP) for cardiac anatomy and function assessment.
  • Employing T2-weighted imaging (T2-W) and T2 mapping for myocardial edema detection.
  • Applying late gadolinium enhancement (LGE) and T1 mapping/extracellular volume fraction (ECV) for fibrosis quantification.

Main Results:

  • CMR parameters effectively identify myocardial edema and fibrosis in ARD patients.
  • These parameters are instrumental in making informed treatment decisions.
  • Despite the absence of multicenter studies, CMR applications are widespread in ARD management.

Conclusions:

  • Tissue characterization with CMR enables early and reliable identification of CVD in ARD patients.
  • CMR contributes significantly to the personalized management strategies for ARD patients.
  • CMR imaging is a valuable tool for risk stratification and therapeutic guidance in this population.
Abstract

Keywords:
Cardiovascular magnetic resonancecoronary artery diseasemyocardial inflammationmyocardial perfusionfibrosisvasculitis

More Related Videos

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats08:41

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats

Published on: July 19, 2013

12.9K
Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.8K

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
122
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
138
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
126
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
160
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
52
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
88