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Leukemia cutis and eccrine squamous syringometaplasia
R Bouceiro-Mendes1, S Antunes-Duarte, M Aguado-Lobo
1Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Dermatology Department, Lisbon. rita.bouceiro.mendes@gmail.com.
Dermatology Online Journal
|August 13, 2021
Summary
Eccrine squamous syringometaplasia (ESS) is a histological finding in skin ducts. This case reveals ESS occurring in leukemia cutis lesions, even without chemotherapy treatment.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Eccrine squamous syringometaplasia (ESS) is a histological pattern characterized by squamous metaplasia of eccrine ducts.
- ESS is often associated with chemotherapy but can also occur in various non-specific conditions like infections, neoplasms, and inflammatory skin diseases.
Observation:
- A 75-year-old male patient presented with lesions of leukemia cutis (LC).
- The patient had a recent diagnosis of acute myeloid leukemia (AML).
Findings:
- The histological examination of the LC lesions revealed the presence of eccrine squamous syringometaplasia (ESS).
- Notably, the patient was not undergoing chemotherapy at the time of the biopsy.
Implications:
- This case highlights that ESS can occur in leukemia cutis lesions independently of chemotherapy.
- It expands the differential diagnosis for ESS, suggesting a potential association with hematologic malignancies beyond direct treatment effects.
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